BORIS Theses

BORIS Theses
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Outcomes and long-term follow-up of 106 cats treated with subcutaneous ureteral bypass for ureteral obstruction

Pestelacci, Sabina (2022). Outcomes and long-term follow-up of 106 cats treated with subcutaneous ureteral bypass for ureteral obstruction. (Thesis). Universität Bern, Bern

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Subcutaneous ureteral bypass (SUB) is the main therapy for cats with benign ureteral obstructions (UO). However, variables associated with outcome and disease progression remain to be characterized. In this retrospective study, medical records of all cats treated with SUB (Vetsuisse Faculty of Bern, 2014-2020) were reviewed (n=106 cats). Short-term outcome was defined as hospital discharge; long-term outcome as the rate of progression of serum creatinine >120 days after surgery. Hospital discharge rate was 86%. During follow-up, 22% of the cats required revision surgeries and 27% had ≥1 positive urine culture. Median survival time was 1.9 years (95% confidence interval, 1.4-3.2), with 50% urinary-related causes of death. Of the clinical variables available at presentation, only younger age was associated with better short-term outcome (P=.008). A lower creatinine at discharge was associated with favorable long-term outcome (P=.02). The median increase in serum creatinine during follow-up was 0.14 mg/dL/year (interquartile range, -0.05 to 0.83); 75% of the cats were classified as stable. Positive urine cultures at the time of diagnosis or treatment with hemodialysis before surgery for severe azotemia were not associated with outcome. In conclusion, SUB devices are a feasible option to treat cats with UO, associated with slow progression of chronic kidney disease and long survival time. Positive urine culture or severe azotemia at presentation do not predict a worse outcome.

Item Type: Thesis
Dissertation Type: Single
Date of Defense: 18 February 2022
Subjects: 500 Science > 590 Animals (Zoology)
600 Technology > 610 Medicine & health
Institute / Center: 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
Depositing User: Hammer Igor
Date Deposited: 26 Sep 2023 14:16
Last Modified: 01 Oct 2023 08:02

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