Zakharova, Elena (2022). Peptides and Peptide Dendrimers as Drug Delivery and Anticancer Agents. (Thesis). Universität Bern, Bern

Preview

Text 22zakharova_e.pdf - Thesis Available under License Creative Commons: Attribution (CC-BY 4.0). Download (9MB) | Preview

Abstract

Peptides are compounds, that are involved in a wide range of biological applications. Use of peptides in cancer therapy can become an alternative strategy to conventional chemotherapy, which is often complicated by increased resistance and detrimental side effects. In the beginning of this thesis, a general introduction gives short overview of current problems of cancer treatment (Chapter 1). The experimental work is divided into two parts. In the first part, we investigated peptides and peptide dendrimers as possible delivery vectors for chemotherapy drugs such as doxorubicin and 1,2-diaminocyclohexane-Platinum(II) (Chapters 2 and 3). We designed suitable drug delivery strategies and assessed the anticancer activity of conjugates. In the second part, we aimed to develop different peptidic molecules, which can directly act as anticancer agents. By using machine learning approaches, we generated linear, non-hemolytic anticancer peptides (Chapter 4). Further biological evaluations revealed membranolytic and mitochondria targeting properties of selected anticancer peptides. In the Chapter 5 we reported for the first time anticancer properties of peptide dendrimers and presented our attempts to build peptide dendrimers with so-called “isopeptide bonds”.

Item Type:	Thesis
Dissertation Type:	Single
Date of Defense:	17 October 2022
Subjects:	500 Science > 540 Chemistry 500 Science > 570 Life sciences; biology
Institute / Center:	08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)
Depositing User:	Sarah Stalder
Date Deposited:	01 Nov 2023 11:58
Last Modified:	01 Nov 2023 23:25
URI:	https://boristheses.unibe.ch/id/eprint/4642

Actions (login required)

View Item